Search results for " Cytokine Polymorphisms"

showing 3 items of 3 documents

Analysis of IL-6, IL-10 and IL-17 genetic polymorphisms as risk factors for sepsis development in burned patients.

2012

Abstract Infection risk, sepsis and mortality after severe burn are primarily determined by patient age, burn size, and depth. Whether genetic differences contribute to otherwise unexpected variability in outcomes is unknown. We sought to determine whether there was an association between IL-6, IL-10 and IL-17 polymorphisms with cytokine production and development of sepsis. We evaluated 71 patients with burns ≥15% TBSA and 109 healthy subjects. The genotypes of IL-6 (−174C/G), IL-10 (−819C/T and −1082A/G) and IL-17 (7488T/C) polymorphisms were identified applying polymerase chain reaction protocols. The cytokine levels in serum were determined with enzyme-linked immunoabsorbent assays. Our…

AdultMaleBurns Cytokine polymorphisms sepsis riskAdolescentGenotypemedicine.medical_treatmentCritical Care and Intensive Care MedicinePolymerase Chain Reactionlaw.inventionSepsisYoung AdultlawRisk FactorsSepsisGenotypeSettore MED/05 - Patologia ClinicaMedicineHumansInterleukin 6Polymerase chain reactionAgedAged 80 and overPolymorphism Geneticbiologybusiness.industryInterleukin-6Interleukin-17General MedicineMiddle Agedmedicine.diseaseGenotype frequencyInterleukin-10Interleukin 10CytokineImmunologyEmergency Medicinebiology.proteinSurgeryFemaleInterleukin 17businessBurnsBurns : journal of the International Society for Burn Injuries
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Cytokine Gene Polymorphisms and Breast Cancer Susceptibility

2006

Human breast cancer (BC) is characterized by a considerable clinical heterogeneity. Steroid hormone receptor expression and growth factor receptor expression have been considered suitable diagnostic and prognostic markers, whereas mutations of oncosuppressor and gatekeeper genes have been found associated with an increased risk for this malignancy. To evaluate the role that polymorphisms of genes involved in the regulation of inflammatory response might play in BC susceptibility, we investigated associations between cytokine functionally relevant polymorphisms in 84 BC patients compared to 110 age- and sex-matched controls. TNF-alpha (-308G/A), TGF-beta1 (+869C/T), IL-10 (-1117G/A; -854C/T;…

GeneticsGeneral NeuroscienceHaplotypeCancerBreast NeoplasmsSingle-nucleotide polymorphismBiologymedicine.diseasePolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyBreast cancerHistory and Philosophy of ScienceGenotypemedicineCytokinesHumansbreast cancercytokine genepolymorphismsFemaleGenetic Predisposition to DiseaseRestriction fragment length polymorphismbreast cancer; cytokine polymorphisms; susceptibilityGeneAllele frequencyAnnals of the New York Academy of Sciences
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Role of Cytokine Polymorphisms in the Rhinitis-Asthma Evolution

2014

AAD1. Role of Cytokine Polymorphisms in the Rhinitis-Asthma Evolution G. Santini1, L. Scola1, S. La Piana1, P. Di Gangi1, L. Vaccarino1, M. Bova1, C. R. Balistreri1, D. Lio1, G. Di Lorenzo1 1University of Palermo, Palermo, Italy Background: Several epidemiological studies demonstrate that a timeline from rhinitis to asthma exists, and that rhinitis is a risk factor for asthma. In particular, rhinitis increases the chance of development of asthma by about three times. In addition to environmental factors, genetic factors play an important role in the development of atopic airway diseases. The aim of this study is to analyse the role of cytokine polymorphism in the evolution of rhinitis-asthm…

asthma Cytokine Polymorphisms
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